| PACER | Public Access to Court Electronic Records |
| PAM | Office of Acquisition and Property Management |
| PARIS | Public Assistance Reporting Information System |
| PBGC | Pension Benefit Guaranty Corporation |
| PBS | Public Buildings Service |
| PC | Peace Corps |
| PCAST | President's Council of Advisors on Science and Technology |
| PCBE | President's Council on Bioethics |
| PCC | Panama Canal Commission |
| PCIE | President's Council on Integrity and Effiency (changed to CIGIE) |
| PCII | Protected Critical Infrastructure Information |
| PCLO | Privacy and Civil Liberties Office (changed to OPCL) |
| PCLOB | Privacy and Civil Liberties Oversight Board (unable to verify 8/09) |
| PCPID | President's Committee for People with Intellectual Disabilities |
| PECAD | Production Estimates and Crop Assessment Division |
| PECE | Policy for Evaluation of Conservation Efforts |
| PedNSS | Pediatric Nutrition Surveillance System |
| PEPFAR | President's Emergency Plan for AIDS Relief |
| PFIAB | President's Foreign Intelligence Advisory Board |
| PFPA | Pentagon Force Protection Agency |
| PHA | Public Housing Agency (see PIH) |
| PharmPAC | Pharmacist Professional Advisory Committee |
| PHIL | Public Health Image Library |
| PHIN | Public Health Information Network |
| PHMSA | Pipeline and Hazardous Materials Adminsitration |
| PHPPO | Public Health Practice Program Office (defunct; see Wayback Machine) |
| PHPS | Public Health Prevention Service |
| PHS | Public Health Service (see OPHS) |
| PHTN | Public Health Training Network |
| PIA | Privacy Impact Assessments |
| PIADC | Plum Island Animal Disease Center |
| PIDB | Public Interest Declassification Board |
| PIH | Office of Public and Indian Housing |
| PIN | Public Integrity Section |
| PLLI | National Institute on Postsecondary Education, Libraries, and Lifelong Learning (archive) |
| PM | Bureau of Political-Military Affairs |
| PMB | Office of Policy, Management and Budget |
| PMEL | Pacific Marine Environmental Laboratory |
| PMI | President’s Malaria Initiative |
| PNGV | Partnership for a New Generation of Vehicles |
| PNNL | Pacific Northwest National Laboratory |
| PNSS | Pregnancy Nutrition Surveillance System |
| POTUS | President of the United States |
| POW/MP | Prisoner of War/Missing Personnel |
| PPD | Pentagon Police Department |
| PPQ | Plant Protection and Quarantine |
| PRAO | Professional Responsibility Advisory Office |
| PRC | Postal Regulatory Commission |
| PRM | Bureau of Population, Refugees, and Migration |
| PSC | Program Support Center |
| PSN | Project Safe Neighborhoods |
| PTFP | Public Telecommunications Facilities Program |
| PTO | Patent and Trademark Office |
| PUMS | Public Use Microdata Samples |
| PWBA | Pension and Welfare Benefits Administration (changed to EBSA) |
| PWSD | Public Workforce System Dataset |
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