| TA | Technology Administration (defunct; see Wayback Machine) |
| TAA | Trade Adjustment Assistance for Firms |
| TAATC | Division of Trade Agreement Administration and Technical Cooperation |
| TANF | Temporary Assistance for Needy Families |
| TBAC | Tribal Budget Advisory Council |
| TCAC | Tribal Consultation Advisory Committee |
| TCC | Trade Compliance Center |
| TDA | Trade and Development Agency (see USTDA) |
| TEAS | Trademark Electronic Application System |
| TEFAP | The Emergency Food Assistance Program |
| TEOAF | Treasury Executive Office for Asset Forfeiture |
| TFF | Treasury Forfeiture Fund |
| TIC | Trade Information Center (merged with Export.gov) |
| TIGER Team | Transportation Investment Generating Economic Recovery |
| TIGTA | Treasury Inspector General for Tax Administration |
| TIPS | Terrorism Information and Prevention System (defunct; see Senate hearing) |
| TMA | TRICARE Managment Activity |
| TOP | Technology Opportunities Program |
| TPS | Technical Preservation Services |
| TRI | Toxics Release Inventory |
| TSA | Transportation Security Administration |
| TSC | Terrorist Screening Center |
| TSI | Transportation Safety Institute |
| TSO | TRICARE Support Office |
| TSP | Thrift Savings Plan |
| TTB | Alcohol and Tobacoo Tax and Trade Bureau |
| TTN | Technology Transfer Network |
| TVA | Tennessee Valley Authority |
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